FigureĀ 3.
The final structure of EC formed on the surface of a membrane. FVIIa, sTF, and FX are shown in orange, blue, and purple, respectively. Membrane lipids are visible at the bottom in yellow, blue and red. Note that both FVIIa- and FX-GLA domains, as well as the bottom portion of sTF, remain engaged with the membrane. In the complex, TF plays the role of aligning the catalytic domain of FVIIa (SPD) with the protease domain of FX (top 2 globular domains). A PDB file of this structure (TF-FVIIa-FX-membrane_model.pdb) is available for download at https://doi.org/10.17605/OSF.IO/P8CSB.