Other significant factors affecting outcome in newly diagnosed APL.P values shown were those obtained from univariate log-rank test. Table 2 gives the corresponding P values on multivariate Cox regression analysis. (A) Impact of CNS involvement at presentation on 60-day survival. (B) Impact of sex on post–60-day OS. (C) Impact of age on post–60-day OS. (D) Impact of therapy-related APL on post–60-day OS. (E) Impact of CNS involvement at presentation on post–60-day OS. (F) Impact of sex on RFS. (G) Impact of CNS involvement at presentation on RFS. (H) Impact of year of diagnosis on RFS. (I) Impact of age on OS. (J) Impact of APL-DS on OS. (K) Impact of CNS involvement at presentation on OS.