Changes in total symptom score over time. (A) Waterfall plot shows percentage change from baseline in TSS at week 24 for individual patients in cohorts 1a and 1b; (B) Kaplan-Meier curve depicts the probability of maintaining TSS₅₀ for patients who achieved it at any time on study. ^aN, number of patients with nonmissing percent change in TSS from baseline at week 24; ^bfrom time that it was achieved.