Patients with AR genomic lesions and MRD positivity have poor outcomes compared with both SR patients and AR patients who achieve MRD negativity. Kaplan-Meier curves assessed (A) OS and (B) RFS for total genomic study cohort patients with TP1 MRD data available (49 patients). (C) OS and (D) RFS for total genomic study cohort patients with TP2 MRD data available (49 patients). Statistical significance was determined by the log-rank survival (Mantel-Cox) test.