Enrichment of heterochromatin H3K27me3 at the lost enhancers in CLL B cells. (A) Box plots showing the fold change of the H3K27me3 intensity at the H3K27me3 increased or decreased peaks in CLL B cells. The altered peaks were cut off at P <.01 and fold change of >2 between CLL and NBCs. (B) A snapshot showing the indicated histone marks at the DENND3 gene locus in CLL B cells. (C) Venn diagrams showing the overlap of the indicated peaks. (D) Representative metagene heat maps showing H3K4me1, H3K27ac, and H3K27me3 intensity of the indicated peaks in panel C. (E) Pathways associated with the genes putatively regulated by the H3K4me1^down/H3K27ac^down/H3K27me3^up peaks in CLL. (F) A snapshot showing histone modification enrichment at gene locus IL-6.