Enrichment of heterochromatin H3K9me3 at the lost enhancers in CLL B cells. (A) Box plots showing the fold change of the H3K9me3 intensity at the H3K9me3 increased or decreased peaks in CLL B cells. The altered peaks were cut off at P < .01 and fold change of >2 between CLL and NBCs. (B) A snapshot showing the indicated histone marks at the MAP4K4 gene locus in CLL B cells. (C) Venn diagrams showing the overlap of the indicated peaks. (D) Representative metagene heatmaps showing H3K4me1, H3K27ac, and H3K9me3 intensity of the indicated peaks in panel C. (E) Pathways associated with the genes putatively regulated by the H3K4me1^down/H3K27ac^down/H3K9me3^up peaks in CLL.