The enrichment of heterochromatin at CLL lost enhancers is already detectable at the MBL stage. (A) Metagene heatmaps showing H3K4me1, H3K27ac, and H3K27me3 intensity at the indicated peaks in indicated samples. (B) Metagene heatmaps showing H3K4me1, H3K27ac, and H3K9me3 intensity at the indicated peaks in indicated samples. (C) A snapshot showing histone modification enrichment at gene locus EBF1. (D) A snapshot showing histone modification enrichment at gene locus LEF1.