Disposition of patients during dose escalation and dose expansion. ∗Patients were enrolled under the modified QW schedule but treated every 2 weeks. Sequence of doses by schedule: modified QW schedule: started at 0.001 mg/kg, followed by 0.01 mg/kg, 0.1 mg/kg, 0.75 mg/kg, and discontinuation of schedule. Q2W: started at 0.4 mg/kg, deescalated to 0.3 mg/kg, followed by 0.2 mg/kg, and discontinuation of schedule. Q3W: started at 0.4 mg/kg, escalated to 0.75 mg/kg, and discontinuation of schedule. Q4W: started at 0.75 mg/kg, escalated to 1.5 mg/kg, followed by 3 and 6 mg/kg; MTD declared at 3 mg/kg. d, day; Dex, dexamethasone; QW, weekly.