Evolution of response to treatment. Response assessment time points at 1, 2, 3, 4, and 5 years are shown with transitions between each. The total height of the columns is proportional to the sample size. The number of patients receiving treatment is shown below the columns. This Sankey diagram represents the transition between 8 states: CR, PR, no response, partial loss of response, loss of response, missing data, treatment interruption, and end of follow-up.