Hematologic-free survival according to mutational status. (A) Kaplan-Meier curve for hematologic evolution–free survival according to the number of additional mutations at diagnosis. The number of patients at risk for each group are shown in the table below the curves. (B) Forest plots representing the multivariable analysis including the following variables: age >60 years, gender, previous thrombosis, leukocytosis >11 G/L, and response at 12 months. (C) Kaplan-Meier curve for hematologic evolution–free survival according to both the presence of additional mutations and the type of treatment received.