RTI caused by S aureus reduced body weight, imbalanced VWF-ADAMTS13 axis, and increased plasma IL-6, CXCL-1, and MCP-1. (A) Schematic of experimental design. (B) Left: body weight changes in S aureus–infected and mock-infected mice (n = 6-8 mice per group). Middle left: representative MRI images on day 6 after infection; white area indicates inflammation, arrows indicate inflammation. Middle right: pulmonary inflammatory index quantification (n = 6-8 mice per group). Right: bacterial count in the lungs, brain, and blood (n = 8 mice per group). (C) Plasma VWF levels (left), ADAMTS13 activity (middle), and VWF:ADAMTS13 activity ratio (right) on day 6 after infection (n = 6-8 mice per group). (D) Plasma TNF-α (left), IL-6 (middle left), CXCL-1 (middle right), and MCP-1 (right) levels on day 6 after infection (n = 6-8 mice per group). Data are presented as mean ± standard error of the mean (SEM). Statistical analysis was performed using a 2-way ANOVA followed by the Šidák post hoc test for panel B (left) and an unpaired t test for panels B (middle),C-D. NS, nonsignificant.