Figure 5.
Preceding RTI caused by SARS-CoV-2 reduced body weight; imbalanced VWF-ADAMTS13 axis; and increased plasma IL-6, CXCL-1, and MCP-1. (A) Schematic of experimental design. (B) Body weight changes in SARS-CoV-2– and mock-infected mice (n = 8 mice per group). (C) SARS-CoV-2 titer in the lungs and brain (n = 8 mice per group). (D) Plasma VWF levels (left), ADAMTS13 activity (middle), and VWF:ADAMTS13 activity ratio (right) on day 3 after infection (n = 8 mice per group). (E) Plasma TNF-α (left), IL-6 (middle left), CXCL-1 (middle right) and MCP-1 (right) levels on day 3 after infection (n = 6-8 mice per group). Data are presented as mean ± SEM. Statistical analysis was performed using a 2-way ANOVA followed by the Šidák post hoc test for panel B and an unpaired t test for panels C-E. NS, nonsignificant.

Preceding RTI caused by SARS-CoV-2 reduced body weight; imbalanced VWF-ADAMTS13 axis; and increased plasma IL-6, CXCL-1, and MCP-1. (A) Schematic of experimental design. (B) Body weight changes in SARS-CoV-2– and mock-infected mice (n = 8 mice per group). (C) SARS-CoV-2 titer in the lungs and brain (n = 8 mice per group). (D) Plasma VWF levels (left), ADAMTS13 activity (middle), and VWF:ADAMTS13 activity ratio (right) on day 3 after infection (n = 8 mice per group). (E) Plasma TNF-α (left), IL-6 (middle left), CXCL-1 (middle right) and MCP-1 (right) levels on day 3 after infection (n = 6-8 mice per group). Data are presented as mean ± SEM. Statistical analysis was performed using a 2-way ANOVA followed by the Šidák post hoc test for panel B and an unpaired t test for panels C-E. NS, nonsignificant.

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