Figure 1.
Markov structure. The Markov structure includes 3 health states: “no joint surgery,” “joint surgery,” and “death.” Within these health states, patients incur a risk of major and minor bleed events each cycle. The risk of joint surgery is dependent on the number of joint bleeds incurred. Risk of death is a function of age and sex.

Markov structure. The Markov structure includes 3 health states: “no joint surgery,” “joint surgery,” and “death.” Within these health states, patients incur a risk of major and minor bleed events each cycle. The risk of joint surgery is dependent on the number of joint bleeds incurred. Risk of death is a function of age and sex.

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