Cotitration of increasing amounts of recombinant WT DNMT3A relative to different mutant counterparts. (A-D) Cotitration of WT DNMT3A compared to DNMT3A R635W (A), DNMT3A R688C (B), DNMT3A R882C (C) and DNMT3A A884V (D). ∗Samples run on different gels in the same experiment and imaged at the same time due to logistic limitations.