Methylation damage burden is increased in patients carrying 2 DNMT3A mutations, particularly when these mutations reside at the DNMT3A-TDG interaction surface. (A) Box plot for SBS1 score grouped by DNMT3A mutant group. Each point depicts the SBS1 score of an individual patient. The color of each data point represents the quantity of DNMT3A mutations situated within the DNMT3A-TDG interface. (B) Box plots for SBS1 score grouped by the number of DNMT3A mutations located at the DNMT3A-TDG interaction surface. The color of each data point represents the DNMT3A mutant group.