The distribution of the HADS categories for anxiety and depression at enrollment, 12 months, and the changes from enrollment to 12 months. (A) Anxiety categories as determined by the HADS at enrollment. (B) Depression categories as determined by the HADS at enrollment. (C) Anxiety categories as determined by the HADS at 12 months. (D) Depression categories as determined by the HADS at 12 months. (E) Change in anxiety categories as determined by the HADS from enrollment to 12 months. (F) Change in depression categories as determined by the HADS from enrollment to 12 months.