Figure 4.
High-dimensional CyTOF analysis of serial bone marrow samples in nonresponder patient 18. (A) Uniform manifold approximation and projection plots display the expression of CD45, CD34, BCL-2, BCL-XL, MCL-1, and clustering. (B) The percentages of persistent blast subpopulation (Pop4) and the expression of BCL-2, BCL-XL, and MCL-1 at the indicated time points. (C) Heat map displays the expression level of BCL-2, BCL-XL, and MCL-1 in Pop4 and in total population (Total Pop). (D) Expression ratio of EOC1 and EOC2 to baseline (BL) in Pop4.

High-dimensional CyTOF analysis of serial bone marrow samples in nonresponder patient 18. (A) Uniform manifold approximation and projection plots display the expression of CD45, CD34, BCL-2, BCL-XL, MCL-1, and clustering. (B) The percentages of persistent blast subpopulation (Pop4) and the expression of BCL-2, BCL-XL, and MCL-1 at the indicated time points. (C) Heat map displays the expression level of BCL-2, BCL-XL, and MCL-1 in Pop4 and in total population (Total Pop). (D) Expression ratio of EOC1 and EOC2 to baseline (BL) in Pop4.

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