Overall concordance and discordance of eligibility criteria with drug safety signals. A safety signal (SS) is defined as the presence of a potential drug safety issue as identified by literature and pharmacist review. A limit is defined as eligibility criteria that is restrictive. The presence or absence of SS and limits for the following variables in each trial were assessed: EF, QTc limits, HIV, hepatitis B, hepatitis C, creatinine, ALT, AST, and total bilirubin. Stacked bars show concordance (shades of blue) and discordance (red and orange) between eligibility criteria and relevant drug safety signals. Numbers within the bars indicate the number of trials.