An iPSC model of ETO2::GLIS2-driven acute megakaryoblastic leukemia. Boudia et al genome edited healthy iPSCs to express the ETO2::GLIS2 oncofusion. After differentiation to blood, cells were transplanted to mice and leukemia initiation and progression was evaluated. The features observed were compared with patient samples. The authors also generated ETO2::GLIS2 iPSCs deficient in DLX3 (KO), which resulted in loss of the leukemia-initiating ability in mice. iPSC, induced pluripotent stem cell; KO, knockout; WT, wild-type. Professional illustration by Patrick Lane, ScEYEnce Studios.

An iPSC model of ETO2::GLIS2-driven acute megakaryoblastic leukemia. Boudia et al genome edited healthy iPSCs to express the ETO2::GLIS2 oncofusion. After differentiation to blood, cells were transplanted to mice and leukemia initiation and progression was evaluated. The features observed were compared with patient samples. The authors also generated ETO2::GLIS2 iPSCs deficient in DLX3 (KO), which resulted in loss of the leukemia-initiating ability in mice. iPSC, induced pluripotent stem cell; KO, knockout; WT, wild-type. Professional illustration by Patrick Lane, ScEYEnce Studios.

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