Prognostic impact of ctDNA levels and ST2/BN2 molecular clusters. Kaplan-Meier estimates of (A) PFS and (B) OS according to ctDNA levels and ST2/BN2 clusters. Patients with ctDNA of <2.5 log₁₀ hGE/mL and/or assigned to BN2/ST2 clusters are represented by the blue curve. Patients with ctDNA of ≥2.5 log₁₀ hGE/mL and not assigned to cluster BN2/ST2 cluster are represented by the red curve. Multivariate analysis of (C) PFS and (D) OS including ctDNA levels, BN2/ST2 cluster, International Prognostic Index (IPI) score, and cell of origin.