Differential Ab responses between responders and nonresponders to EBVST immunotherapy. The volcano plots show the difference in IgA and IgG levels (SSI) between responders (n = 36) and non-responders (n = 20) to EBVST immunotherapy at preinfusion and 2-week (2 wk), 4-week (4 wk), and 3-month (3 mo) postinfusion time points. The x-axis represents the fold change (ratio of SSI for responders vs nonresponders), whereas the y-axis shows the corresponding t test log 10 (P values.) IgA Abs are shown in red, and IgG Abs are shown in blue. Abs with a coefficient of variation (CV) <30% are included in the analysis (IgA = 202; IgG = 74). The dashed lines represent the nominally significant P value threshold.