Transcriptional changes identified in expanded NK cells caused by drug and target cell coculture. (A) Dot plot of selected genes upregulated and downregulated in NK cells exposed to K562 and drugs. Transcriptional data used for comparison are NK cells from coculture alone (NK-K562-DMSO). Dots encircled by gray indicate false discovery rate (FDR) <0.1. Magnitudes of gene fold changes are depicted by dot color, and the magnitude of FDR is depicted by dot size. FDR was calculated using the Benjamini-Hochberg (BH) test. (B-E) Volcano plots of differentially expressed genes from selected conditions of NK-target cell coculture and drug. Genes with an adjusted P value (BH) < .1 are colored red or blue. (F) Violin plot of IFNG expression in the NK coculture conditions.