Experimental plan of DAPS-ITP RCT. Eligible patients randomized to arm A received dapsone at 100 mg per day in combination with prednisone at a daily dose of 1 mg/kg for 2 weeks, then tapered, and stopped over 1 week for a total of 3 consecutive weeks. After prednisone withdrawal, patients in this arm continued to receive dapsone at the same dose for a total of 12 months unless they did not respond to treatment or in case of a dapsone-related AE graded ≥3. In that case, patients were classified as nonresponders and the subsequent treatment was chosen by the investigator at his/her discretion based on standard of care. Patients randomized to arm B received prednisone alone at a dose of 1 mg/kg per day for 2 weeks, then tapered, and stopped over a week for a total duration of 3 consecutive weeks. After this 3-week period, patients in arm B remained untreated and were monitored. In case of relapse, patients were classified as nonresponders and the subsequent treatment was chosen at the investigator’s discretion based on standard care. M12, Month 12; R, response; CR, complete response.