Figure 1. HDX patterns for the ADAMTS13... | American Society of Hematology

Figure 1.

$HDX patterns for the ADAMTS13 CUB1-2 domains. (A-B) HDX heat maps in the rainbow color scale (blue, low HDX; red, high HDX) plotted onto the ADAMTS13 CUB1-2 crystal structure (PDB ID: 7B01) reflecting the relative fractional deuterium uptake at the 10, 100, 500, and 1000 seconds incubation time points in absence (A) and presence (B) of the 17G2 mAb. In these annotated structures, the antiparallel β-strands are intertwined by loops or an α-helix to form a jelly roll fold.8$

HDX patterns for the ADAMTS13 CUB1-2 domains. (A-B) HDX heat maps in the rainbow color scale (blue, low HDX; red, high HDX) plotted onto the ADAMTS13 CUB1-2 crystal structure (PDB ID: 7B01) reflecting the relative fractional deuterium uptake at the 10, 100, 500, and 1000 seconds incubation time points in absence (A) and presence (B) of the 17G2 mAb. In these annotated structures, the antiparallel β-strands are intertwined by loops or an α-helix to form a jelly roll fold.⁸

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