Overlaps and contrasts between the 3 gene lists. (A) A modified Venn diagram illustrating the intersections between the DLBCL, FL, and BL gene lists with nested circles representing the Tier 1 and Tier 2 genes for each entity. When not all genes in a group can be shown because of space limitations, these lists end in an ellipsis. Tier 3 genes are excluded to simplify the figure. Representative genes in each intersection are shown but re not exhaustive for the larger intersections. Intersections sharing no genes are denoted with the “∅” symbol. (B) A 3-dimensional plot showing the relative enrichment of mutations in each entity relative to the other 2. Each axis represents the log (odds ratio) from a Fisher exact test comparing the 2 entities indicated on that axis. For example, the DLBCL vs BL dimension is based on the relative incidence of mutations in these genes in a large collection of DLBCL and BL tumors. The points represent a selection of representative genes from the Tier 1 intersections from the Venn diagram. Points are colored according to the gene list(s) in which they reside. The 3 arrows indicate the location of points with relative enrichments in each of the entities. Most of the DLBCL and BL genomes used for this analysis were described in our recent study.54 Additional DLBCLs and FLs were originally sequenced as part of the ICGC malignant lymphoma (Germany) MALY-DE project,20 a Genome Canada-funded project in BC Cancer,49,64 or the Burkitt Lymphoma Genome Sequencing Project.12 The DLBCL exomes largely from the study by Schmitz et al,5 Chapuy et al,6 Lohr et al,22 and our previous studies.34,64
