Patterns of AML genomic evolution from diag to REL. (A-C) Fish plots detailing the expansion and contraction of specific variants within individual patients from diag to REL. (D) Classification of evolutionary patterns at the time of REL (left) or REF disease (right) across the entire cohort. (E) Bar plot detailing the type of REL patterns observed in patients jointly stratified by DNMT3A, TET2, and ASXL1 mut status.