Figure 1.
![JAK2 46/1 haplotype influences PD-L1 expression levels. (A) The percentage of PD-L1–expressing cells, measured by flow cytometry, in different peripheral blood cell populations from healthy donors (46/1 nullizygous [blue] and 46/1 homozygous [red]; n = 37 each). ∗P < .05 (nonparametric Kruskal-Wallis test). (B) PD-L1 protein levels, determined by enzyme-linked immunosorbent assay and expressed as PD-L1/total protein (pg/μg) in CD34+ cells obtained from bone marrow of JAK2-positive patients with MPN (46/1 nullizygous [blue], n = 11; 46/1 homozygous [red], n = 9). Error bars indicate standard error of the mean. B, B lymphocytes; NK, natural killer cells; NKT, natural killer T cells; T, T lymphocytes.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/145/19/10.1182_blood.2023023787/1/blood_bld-2023-023787-gr1.jpeg?Expires=1749852093&Signature=tIBzoKRv2yoPl9YQA08oQMwV88YDYtLyQQLEI9jVP~qikG2XvreQWvLQO8cR1XZf06r2dy3bKIkTTOLgWPyECVarJdMewrXiEcpb-vhkA5~zKuHetA6~4dmw9ko4CKOpm3p16hkDLK3v7x9ElaG-mYY3joqo87zbrDDtKyq1iVSEc3WUR6zt0Kkw5xR3cDmr4JXJrbh0j~m2FXIeiPDJg21F3zOxdegFakIVAoXcHFtSKd6Tqe5U0aPSomipLcoz6FBWzEVhtZ4biyVwj8y8n2VIAWKBYfIZiGGev~6Vg5IqEXtdLCrVuMYjh5Ri7~hv~8mMwzDjTSwW7WX8fv0Cqg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
JAK2 46/1 haplotype influences PD-L1 expression levels. (A) The percentage of PD-L1–expressing cells, measured by flow cytometry, in different peripheral blood cell populations from healthy donors (46/1 nullizygous [blue] and 46/1 homozygous [red]; n = 37 each). ∗P < .05 (nonparametric Kruskal-Wallis test). (B) PD-L1 protein levels, determined by enzyme-linked immunosorbent assay and expressed as PD-L1/total protein (pg/μg) in CD34+ cells obtained from bone marrow of JAK2-positive patients with MPN (46/1 nullizygous [blue], n = 11; 46/1 homozygous [red], n = 9). Error bars indicate standard error of the mean. B, B lymphocytes; NK, natural killer cells; NKT, natural killer T cells; T, T lymphocytes.
