Chromatin contacts of JAK2 with the PD-L1 locus differ between the nonrisk and the 46/1 haplotype. Visualization of a 1.6 Mb region from human chromosome 9, spanning the JAK2 and PDL1/2 loci (hg19 chr9:4300000-5900000). Chromatin interactions established from the 7 distinct genomic regions or viewpoints (VP2, VP3, VP4, VP8, VP10, VP5, and VP6; genomic coordinates in supplemental Table 2) are shown as spider plots. Healthy individuals who were 46/1 nullizygous (green and light green, n = 2) or 46/1 homozygous (blue and light blue, n = 2) are shown for each VP, with differences between them around PD-L1/2 indicated. Regions corresponding to the 46/1 haplotype and the PDL-1/2 loci are boxed. Black horizontal arrows below the University of California Santa Cruz browser view indicate the position of all genes in the region, and the names of those referred to in this study are included. On the right of each spider plot, normalized read counts (or contacts) are shown for both PD-L1 (red) and PD-L2 (blue). As indicated, the left column for each locus represents 46/1 homozygous (Hom) and right column 46/1 nullizygous (Null). As an example, there is a marked reduction in normalized read counts between VP2 and PD-L1 on comparison of 46/1 homozygotes with 46/1 nullizygotes. There is also a reduction in the interaction between VP2 and PD-L2, but this is much more modest.