Multiclonal FLT3-ITD mutations and RFS. (A) 54 participants were found to have multiple FLT3-ITD clones using the MRD assay peri-HCT. The Kaplan-Meier curve depicts RFS, irrespective of treatment arm, for these 54 participants compared with all other participants. (B) RFS for these same 54 participants compared with those with no MRD before and after HCT or those with only a single FLT3-ITD clone detected either before and after HCT. (C) RFS for participants on the placebo arm according to peri-HCT FLT3-ITD MRD status. The P value refers to the comparison between the “no MRD” and “single-clone MRD.” The P value comparing the single-clone and multiclonal MRD curves is .022 (not shown). (D) RFS for participants on the gilteritinib arm according to peri-HCT FLT3-ITD MRD status. The P value refers to the comparison between the “no MRD” and “multiclonal MRD.” The P value comparing “no MRD” and “single-clonal MRD” curves is .044 (not shown). HR, hazard ratio.