Figure 2.
PRMT5 expression in monocytes and dendritic cells increases with the induction of HLH. (A) tSNE plot of dendritic cells (D), monocytes (M), and neutrophils (N), with heat maps showing identifying marks. D, CD11c+I-A/I-E+; M, Ly6C+Ly6G–; N, Ly6CloLy6G+. (B) Heat map of PRMT5 expression with the same clustering as shown in panel A. (C) Median fluorescent intensity (MFI) of total myeloid cells (D + M + N), monocytes, neutrophils, and dendritic cells positive for PRMT5 expression. Error bars show standard deviation. Multiple unpaired t tests with the Holm-Šídák method were used to determine statistical significance in panel C. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.

PRMT5 expression in monocytes and dendritic cells increases with the induction of HLH. (A) tSNE plot of dendritic cells (D), monocytes (M), and neutrophils (N), with heat maps showing identifying marks. D, CD11c+I-A/I-E+; M, Ly6C+Ly6G–; N, Ly6CloLy6G+. (B) Heat map of PRMT5 expression with the same clustering as shown in panel A. (C) Median fluorescent intensity (MFI) of total myeloid cells (D + M + N), monocytes, neutrophils, and dendritic cells positive for PRMT5 expression. Error bars show standard deviation. Multiple unpaired t tests with the Holm-Šídák method were used to determine statistical significance in panel C. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.

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