Plasma levels of inflammatory cytokines are reduced with PRMT5 inhibition. (A) Concentration of IFN-γ in plasma as determined by ELISA in healthy mice, induced HLH with no TX, induced HLH with Rux TX, or HLH with PRT382 TX started on day 0 (9 days of treatment), 2 (7 days of treatment), or 4 (5 days of TX). Plasma levels of (B) IL-6, (C) IL-1β, and (D) IL-18 as determined by ELISA in healthy mice, induced HLH with no TX, induced HLH with Rux TX, or with PRT382 TX started on day 0. Error bars show standard deviation. One-way ANOVAs with Tukey multiple comparisons were used to determine significance. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.