Proportion of cells returned to normal levels with PRT382 TX. The percentage of all singlets that (A) CD4 T cells, CD8 T cells, and NK cells or (B) myeloid cells (D + M + N), dendritic cells, monocytes, and neutrophils make up in healthy mice, those with induced HLH, with Rux TX, or with PRT382 TX started on day 0. Error bars show standard deviation. A 2-way ANOVA with Sidak's multiple comparisons was used to determine significance. Note: no comparison between HLH no TX and HLH Rux was found to be significant. One outlier was removed from the healthy cohort for myeloid cells. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. DCs, dendritic cells.