Treatment characteristics and outcome. (A) The percentage of complete remission is depicted according to the most frequent treatments. (B) OS analysis for the whole cohort of patients with MH. (C) Forest plot representing factors associated with OS. CHOP, cyclophosphamide-doxorubicin-vincristine-prednisolone; ICE, ifosfamide-carboplatin-etoposide; ref, reference; TOTEM, topotecan-temozolomide.