Potential mechanisms linking histo-blood group ABO system transferase with venous thromboembolism. Arrow 1: Histo-blood group ABO system transferase (BGAT) adds N-acetylgalactosamine or galactose sugar moiety to transform the H antigen on red cells to A or B antigens, respectively. Arrow 2: BGAT-mediated glycosylation of von Willebrand factor (VWF) leads to elevated levels of VWF and factor VIII in non-O blood groups, thereby increasing the risk of VTE. Arrow 3: BGAT-mediated glycosylation of other proteins could also increase the risk of VTE by unknown mechanisms.

Potential mechanisms linking histo-blood group ABO system transferase with venous thromboembolism. Arrow 1: Histo-blood group ABO system transferase (BGAT) adds N-acetylgalactosamine or galactose sugar moiety to transform the H antigen on red cells to A or B antigens, respectively. Arrow 2: BGAT-mediated glycosylation of von Willebrand factor (VWF) leads to elevated levels of VWF and factor VIII in non-O blood groups, thereby increasing the risk of VTE. Arrow 3: BGAT-mediated glycosylation of other proteins could also increase the risk of VTE by unknown mechanisms.

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