Figure 6.
Clashes predicted between the IKZF1 degron and Len bound to WT and p.P352S CRBN constructs. (A) Unfavorable contacts shown as orange dashes between Len bound to WT CRBN (C atoms shown in light blue with proline 352 highlighted) and IKZF1 degron atoms from PDB 6h0f (C atoms in yellow with glycine 151 highlighted) after structural alignment on CRBN-binding site residues. (B) A larger number of clashes is predicted between the IKZF1 degron and Len bound to the p.P352S CRBN construct (representative conformation from MD; C atoms in orange with serine 352 highlighted). (C) Distribution of clash volumes calculated between heavy atoms of the IKZF1 degron and Len in MD trajectory frames of the WT (blue box), p.P352S (orange), and p.F381S (green) CRBN constructs.

Clashes predicted between the IKZF1 degron and Len bound to WT and p.P352S CRBN constructs. (A) Unfavorable contacts shown as orange dashes between Len bound to WT CRBN (C atoms shown in light blue with proline 352 highlighted) and IKZF1 degron atoms from PDB 6h0f (C atoms in yellow with glycine 151 highlighted) after structural alignment on CRBN-binding site residues. (B) A larger number of clashes is predicted between the IKZF1 degron and Len bound to the p.P352S CRBN construct (representative conformation from MD; C atoms in orange with serine 352 highlighted). (C) Distribution of clash volumes calculated between heavy atoms of the IKZF1 degron and Len in MD trajectory frames of the WT (blue box), p.P352S (orange), and p.F381S (green) CRBN constructs.

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