AOC is characterized by increased plasmin and loss of functional fibrinogen. Fibrinogen levels in the plasma samples from patients with AOC, patients with severe PPH without AOC, and nonbleeding pregnant controls were measured by (A) Clauss assay and as (B) total antigen, and (C) the ratio of Clauss:antigenic fibrinogen was then calculated. (D) PAP complexes and (E) thrombin/antithrombin complexes are illustrated. (F) D-dimer levels in cases of PPH with and without AOC grouped based on those that scored positive (score ≥ 26) or negative (score ≤25) on the ISTH criteria for obstetric DIC. Data are median (IQR). Analysis was by Kruskal-Wallis 1-way analysis of variance and Mann-Whitney U test with Bonferroni correction.