Dynamic changes in hemostatic parameters in the case study of AOC. (A) Clauss and antigenic fibrinogen levels measured during the bleed and the response to an infusion of 6 g of fibrinogen concentrate. The increment for Clauss fibrinogen (orange arrow) is approximately half that found for antigenic (blue arrow). The measured blood loss at the time of each sample is found in pink. (B) The levels of PAP complexes, D-dimer, fragment D, and plasmin generation capacity at each time point. The time of the tranexamic acid (TXA) infusion is illustrated.