Kaplan-Meier curves of the 3 subgroups as defined by TP53 VAF and cytogenetics. Among all covariates included, CART identified VAF as the most significant prognostic variable and cytogenetics as the second most prognostic for PFS. These 2 variables formed an algorithm with 3 prognostic subgroups: cohort of patients with TP53 mutation VAF ≥ 50 was the worst prognostic group with 2-year PFS of 3%. Cohort of patients with TP53 mutation VAF < 50% and who did not have complex/5q/7q cytogenetic abnormalities represented the best prognostic group with 20-year PFS of 60%. Finally, the cohort of patients with TP53 mutation VAF < 50% but having complex cytogenetics or 5q or 7q abnormalities had 2-year PFS of 22%.