Human and mouse genes linked to hemostasis or platelet-related phenotypes. (A) Numbers are shown of phenotyped orthologous human and mouse genes with scores for bleeding, thrombophilia (arterial thrombosis for mice), platelet function/morphology/count, coagulation (including fibrinolysis), and erythrocyte characteristics. (B) Classification scheme used for protein localization and function (classes C01-C22). (C) Human genes linked to bleeding and platelet traits per class. Colored bars indicate reference genes linked to platelet function (orange), thrombocytopenia (black) or both (brown). Gray boxes represent novel genes (names indicated); for phenotypic descriptions and data sources, see supplemental Table 13.