Comparison of SASA of DDB1 cleft in WT and deleted structures. (A) The structure of CRBN (silver) complexed with DDB1 (orange), where the DDB1 cleft is demonstrated in surface representation, where each residue type color is found; red color demonstrates negatively charged, blue for positively charged, green for polar, and white for hydrophobic residues. (B) SASA histogram of all simulations. (C) Nonbonded energy histogram of all simulations. SASA, solvent accessible surface area.