Renal outcomes. (A) Renal response per IMWG criteria² and the median time to sFLC ≤500 mg/L by subgroup. Eighty-five percent of patients had a renal response, with complete renal responses in 50%, partial renal response in 10%, and minor renal response in 25%. Complete renal response is defined as the best posttreatment creatinine clearance (CrCl) of at least 60 mL/min if the baseline eGFR was <50 mL/min per 1.73 m². Partial and minor renal responses to antimyeloma treatment are defined as best CrCl of 30 to 59 mL/min and 15 to 29 mL/min, respectively, if the baseline eGFR was <15 mL/min per 1.73 m². In addition, patients are determined to achieve a minor renal response if best CrCl response is between 30 and 59 mL/min and the baseline eGFR is from 15 to 29 mL/min per 1.73 m². (B) Dialysis outcomes in patients who started dialysis during inpatient hospitalization. Nine patients required dialysis during presentation. Two patients who started on dialysis died within 3 months (age 86 years, from aspiration pneumonia; age 87 years, from disease progression). Of the 7 patients, 4 (57.1%) came off dialysis by 3 months, and 6 (85.7%) were off dialysis at 1 year. ORR, overall response rate.