Cellular and humoral reconstitution within the first year after CAR T-cell treatment. Reconstitution of the hematopoiesis after CAR T-cell therapy for (Ai) MM and (Bi) DLBCL (whiskers indicate SD). A deficiency of CD4⁺, CD8⁺, and CD19⁺ cells was observed in the first year in patients treated with (Aii) anti-BCMA and (Bii) anti-CD19 CAR T cells. Course of immunoglobulin reconstitution after CAR T-cell therapy (whiskers indicate SD) for (Aiii) MM and (Biii) DLBCL. Patients were included in the analysis until progressive disease or reaching the end point of 1 year after CAR T-cell therapy. All data were included in the analysis, containing patients who received G-CSF or IVIG. IVIG, IV immunoglobulin.