Prognostic factors of cellular reconstituion after CAR T-cell treatment. Reconstitution of (A) ANC, (B) lymphocytes, and (C) CD4⁺ T cells depending on (i) CRS grading, (ii) ICANS grading, and (iii) HEMATOTOX risk in patients with DLBCL. Squares indicate mean values and whiskers indicate standard deviation. Data were analyzed with a mixed effects model. ICANS grading >1 is associated with lower lymphocyte and CD4⁺ T-cell counts (column factor, P = .02 and P = .01, respectively). Low HEMATOTOX grading was associated with lower lymphocyte and CD4⁺ counts in the long-term follow-up (time × column factor, P = .03 and P = .01, respectively).