Figure 7.
Mutually exclusive binding of APC and FXa to FVa. (A-C) Overlay of the FVa-APC complex (surface) with proT (red cartoon) and FXa (cyan cartoon) bound to FVa in the proT-prothrombinase complex5,7 in different views (A, right; B, front; C, left). Binding of FXa to the negatively charged region of the A2 domain of FVa directly competes for APC binding and explains why cleavage at R506 and inactivation of FVa are impeded in the prothrombinase complex.27 Interestingly, APC would also compete for binding with the PD of proT but not with the auxiliary Kringles and Gla domain of this zymogen. proT, prothrombin.

Mutually exclusive binding of APC and FXa to FVa. (A-C) Overlay of the FVa-APC complex (surface) with proT (red cartoon) and FXa (cyan cartoon) bound to FVa in the proT-prothrombinase complex5,7 in different views (A, right; B, front; C, left). Binding of FXa to the negatively charged region of the A2 domain of FVa directly competes for APC binding and explains why cleavage at R506 and inactivation of FVa are impeded in the prothrombinase complex.27 Interestingly, APC would also compete for binding with the PD of proT but not with the auxiliary Kringles and Gla domain of this zymogen. proT, prothrombin.

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