TFPI is associated with initial clot formation in whole-blood TEG in COVID-19. (A-E) Simple linear regression analysis of plasma total TPFI vs whole-blood TEG parameters in COVID-19 (n = 60). (F) Simple linear regression analysis of TEG initial clot formation vs thrombin generation lag time (n = 38). (G) Plasma concentration of TF/annexin V double–positive EVs in healthy controls (n = 9) and patients with COVID-19 (n = 10). Data are presented as mean ± standard error and were analyzed using the unpaired t test. ∗∗∗∗P < .0001. max, maximum.