Post-LS outcomes. (A) First-line treatment approach to LS as reported by treating center. Refer to the supplemental Methods for definitions. (B) Rates of CR to first-line treatment of LS. (C) Percentage who received therapy for LS and achieved a CR at any point. One patient who was lost to follow-up was captured as a nonresponder. (D) Percentage of patients alive or dead at the time of data reporting (∗1 patient did not have sufficient follow-up to determine outcome). (E) Kaplan-Meier curve of OS after the diagnosis of LS for those with follow-up. (F) Swimmer plot depicting the post-LS course of those who were alive at the time of data reporting. AZA, azacitidine; chemo, chemotherapy; CR, complete remission; GO, gemtuzumab ozogamicin; HD, high dose; ID, identity; LD, low dose; VEN, venetoclax.