Genetic ancestry in the AML Leucegene and CaG cohorts. PCA (A,C) and UMAP representations (B,D) of the Leucegene and CaG participants, with (A-B) or without (C-D) individuals from the 1000 Genomes Project. Superpopulation refers to the 1000 Genomes Project labels (AFR, AM, EAS, EUR, and SAS). CREGION refers to the region of recruitment for the CaG participants (Leu for patients with AML). In red are outlier Leucegene and CaG samples that cluster with the Italian samples (TSI) from the 1000 Genomes Project (see also supplemental Figure 3). AFR, African; AM, American; EAS, East Asian; EUR, European; Leu, Leucegene; SAS, South Asian.