Transcriptomic differences between pretreatment and posttreatment samples obtained from R/R pts. (A) Volcano plot (left) profile showing the –log10 FDR value and log2 fold change of DEGs in posttreatment vs pretreatment samples obtained from pts who did not respond to or relapsed after VEN/DEC treatment (R/R pts) in the treatment-naive AML cohort (posttreatment, n = 2; pretreatment, n = 5). Dot plot (right) of GSEA results illustrating the top-ranked GO BP terms enriched in the DEGs (FDR < 0.25). Positive enrichment scores indicate upregulation in posttreatment samples. The gene ratio is the percentage of genes that were significantly associated with posttreatment samples among the total number of genes associated with the process. A single asterisk and a double asterisk indicate GO terms associated with energy production and immune response, respectively. (B) Volcano plot profile (left) of DEGs in posttreatment vs pretreatment samples obtained from R/R pts in the non–treatment-naive AML cohort (posttreatment, n = 3; pretreatment, n = 7). Dot plot (right) of GSEA results illustrating the top-ranked GO BP terms enriched in the DEGs (FDR < 0.25). ER, endoplasmic reticulum.