Apoptosis modulators and HDACis potentiate SM response, showing synergistic potential in ALL PDXs. (A) Schematic representation of experimental set up. (B) DRP from 6 different PDXs, screened for synergy between the SM birinapant and 24 anticancer compounds. Each dot represents a sample. Mean, and standard deviation are also shown. Samples included BCP-ALL (PID0083, PID0874, PID0852, PID0859, and PID0858) and T-ALL (PID0884). Within each PDX, n = 1. (C) Heat map depicting mean synergy scores (ZIP, Loewe, HSA, and Bliss) for combinations of SM + apoptosis modulators and SM + HDACis, indicated for each PDX. White represents synergy scores <0; pink represents synergy scores between 0 and +5; red represents synergy scores above +5. HSA, highest single agent; IC₅₀, 50% inhibitory concentration; MSC, mesenchymal stem cell.