Figure 6.
Storage of PR Cryo (PR-CryoFC) does not alter its capacity to resuscitate dWB. (A) Comparison of BTs of all 3 hemostatic adjuncts (day 0) when rescuing dilutional coagulopathy at each shear rate in the microfluidic model using a 2-way ANOVA with a Dunnett multiple comparison test (not significant [ns], P > .05; ∗P ≤ .05; ∗∗P ≤ .01). (B) Coverage of the injury site (pixel count at the given time normalized to the final pixel count of the injury site at the end of the assay = percentage [%] of maximum coverage) within the first 5 minutes of assay for all 3 hemostatic adjuncts (day 0) during dWB resuscitation at high (3500 s−1) shear. (C) Normalized traces (N = 6) of MFI over time (frame rate of 0.12 s−1) represented as percentage of maximum signal for VWF and platelets in rCryo:dWB, rFibCon:dWB, and rPR-CryoFC:dWB at high shear (3500 s−1) for the first 10 minutes of perfusion through the bleeding chamber.

Storage of PR Cryo (PR-CryoFC) does not alter its capacity to resuscitate dWB. (A) Comparison of BTs of all 3 hemostatic adjuncts (day 0) when rescuing dilutional coagulopathy at each shear rate in the microfluidic model using a 2-way ANOVA with a Dunnett multiple comparison test (not significant [ns], P > .05; ∗P ≤ .05; ∗∗P ≤ .01). (B) Coverage of the injury site (pixel count at the given time normalized to the final pixel count of the injury site at the end of the assay = percentage [%] of maximum coverage) within the first 5 minutes of assay for all 3 hemostatic adjuncts (day 0) during dWB resuscitation at high (3500 s−1) shear. (C) Normalized traces (N = 6) of MFI over time (frame rate of 0.12 s−1) represented as percentage of maximum signal for VWF and platelets in rCryo:dWB, rFibCon:dWB, and rPR-CryoFC:dWB at high shear (3500 s−1) for the first 10 minutes of perfusion through the bleeding chamber.

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